Synthesis and Biological Evaluation of Thiazolidine-2, 4-Dione Based Quinazolinone Derivatives for Antimicrobial and Antioxidant Activities

Author(s): Swapna. D*and Rajitha. G

Abstract: A series of thiazolidine-2,4-dione based quinazolinone derivatives (5a–5o) were synthesized by reacting quinazolin-4(3H)-one in sodium hydroxide solution and 5-(substituted benzylidene)-3-(2-chloroacetyl) thiazolidine-2,4-dione. The chemical structure of synthesized compounds was established by IR, 1H NMR and mass spectroscopy and screened for antibacterial and antioxidant activities. The antibacterial evaluation of synthesized compounds was carried out by cup plate method using streptomycin and griseofulvin as standard drugs. The compounds 5d, 5l and 5o showed good activity against both gram positive and gram-negative bacteria with zone of inhibition ranging from 20-26 mm and the compounds 5b, 5i and 5o showed good antifungal activity against Aspergillus niger, Penicillium notatum with zone of inhibition ranging from 20-23 mm. The antioxidant activity was performed by DPPH (2,2-diphenyl-1-picryl-hydrazyl), hydrogen peroxide and nitricoxide scavenging activity methods using ascorbic acid as standard drug. The compounds 5b, 5l and 5o exhibited good antioxidant activity by DPPH, hydrogen peroxide methods and the compounds 5j and 5l exhibited good antioxidant activity by nitricoxide method.

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