Volume 9, Issue 1, January 2019
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Evaluation of CNS Depressant and Muscle Relaxant Activity of Lantana Camara L. Stem and Flowers
Author(s): Javed Khan Pathan*, Girendra Gautam and Arun Kumar Gupta
Abstract: CNS stimulant effect of the ethanolic & aqueous stem & flowers extract of Lantana
camara L. were studied in mice using the benzodiazepine induced sleeping time. Rota rod
bar & Actophotometer has been used to observe the extract’s effect on muscle
coordination & locomotor activity respectively. The extracts effect was compared with
caffeine (a well-known stimulant) indicating better contraction & stimulant properties. In
comparison with diazepam (well-known sedative), extracts gave shorter duration of
sleep; indicating relaxant and less locomotor activity indicating depression action. The
results showed that the extracts at all doses tested, reduced the duration of sleeping
time, when compared to the control group that received distilled water. This difference
in sleeping time was significant (p<0.05) and this was also found to be dose dependent.
The extracts found least comparable activity with caffeine. On Rota rod, the extract had
comparative sedative effect as the animals maintained their balance on the rod through
the entire period of the experiment.
PAGES: 461-468 | 31 VIEWS 31 DOWNLOADS
How To Cite this Article:
Javed Khan Pathan*, Girendra Gautam and Arun Kumar Gupta. Evaluation of CNS Depressant and Muscle Relaxant Activity of Lantana Camara L. Stem and Flowers. 2019; 9(1): 461-468.