Development and Characterization of Doxofylline Hydrogel Beads by Using Single Emulsion Technique

Author(s): Y. Krishna Reddy* and J. Sathyavathi

Abstract: the present work was to development the controlled release Doxofylline hydrogel beads using polymers in various formulations. Doxofylline used to treatment of asthma. These hydrogel beads prepared by using single emulsion technique. Doxofylline causes an irritation in the gastrointestinal mucous membrane and possesses a bitter taste and aftertaste. The half-life in plasma is about 1-2hrs. This makes doxofylline a very good candidate for the formulation of controlled release dosage forms. The formulated were examined by in vitro drug release studies and further perform the stability data for selected or optimized formulation. The work was aimed to develop the controlled release Doxofylline hydrogel beads. Prepared hydrogel beads optimized by considering the drug entrapment efficiency, particle size and in vitro drug release studies. Release of doxofylline was found to be in a controlled manner with increasing polymer content in hydrogel beads and higher release as observed in PH 7.4 medium than that of PH 1.2. In vitro release kinetics of doxofylline from the polymeric beads followed Higuchi kinetics model.

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