A Study on The Safety and Efficacy of Fixed Dose Combination of Amlodipine, Telmisartan And Hydrochlorthiazide In Hypertension

Author(s): E. Bhavani, K. Balireddy*, A. Thanga Thirupati

Abstract: Effective BP control is far away from reality in many patients in spite of advancements in many classes of antihypertensive drug therapy. Use of triple drug combination in the management of hypertension have already been established, however this study was conducted to evaluate the efficacy and safety of triple drug fixed dose combination of Telmisartan 40 mg, Amlodipine 5 mg and Hydrochlorothiazide 12.5mg. Of the 1,47 patients screened, 1,28 were randomized (64 Telmisartan, 64 amlodipine) and 112 finished the investigation (59 Telmisartan, 53 amlodipine). The ITT populace was utilized for the essential examination and included 1263 patients (63 Telmisartan, 63 amlodipine). There were more suspensions with the amlodipine ± HCTZ procedure (11 patients) than with the Telmisartan ± HCTZ technique (46 patients, 7.2%), basically because of AEs (69 patients versus 22 patients individually) and for the most part credited to fringe edema (patients [7.3%] versus two patients [<1%]). Statistic and gauge qualities were all around adjusted between the two treatment procedures, and no factually noteworthy contrasts were watched. The examination was directed in 11 nations at 122 research focuses. By and large, mean age was 54.5 years and mean weight file was 28.4 kg/m2. Most patients were male (55.2%), and the greater part was Caucasian (86.2%). Patients were either organize 1 treatment innocent (33.9%), arrange 2 treatment gullible (13.5%), or uncontrolled on current antihypertensive monotherapy (52.6%). At gauge, MSSBP/MSDBP was 150.2/93.9 mmHg. This triple drug fixed dose combination of Telmisartan, Amlodipine and hydrochlorothiazide was found to be effective and safe option for the optimal management of hypertension.

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