A COMPARISON STUDY BETWEEN OXICONAZOLE BASED NIOSOMAL AND ETHOSOMAL GEL: NEW APPROACH FOR NOVEL DELIVERY SYSTEMS

Author(s): Shaik Harun Rasheed*, Rama Kotaiah Mogili, Chandra Sekhar Kothapalli Bannoth

Abstract: Fungal infection is one of the most common and painful symptoms experienced by both human and veterinary. National Centre for Health Statistics concludes that 80% of patient involved in this problem complained about pain during patient counseling. Pharmaceutical innovation currently has focused on the improvement of novel drug delivery systems (such as liposomes, niosomes, nanosomes, ethosomes, dendrimers, nanoparticles etc) which can increase drug efficacy and potency as compared to other form of drug delivery. The current study focused on to formulate & develop topical antifungal gel in the form of ethosomes and niosomes loaded with oxiconazole as an antifungal drug. Ethosomes and niosomes are well preferred drug delivery system and potential for targeted delivery in anti-cancer, antifungal agents etc. Oxiconazole (OXZ) as an active drug in the form of ethosomes and niosomes could be a novel approach towards skin mediated drug delivery system. Different types of polymers have been introduced to formulate oxiconazole gels. FTIR and DSC techniques used to confirm compatibility study between drug and polymers. Ethosomes and niosomes have been prepared by using injection method and Lipid hydration method respectively. TEM and SEM analysis technique is used to confirm the particle size, shape and morphology of the prepared oxiconazole gel. Particle size played an important role for easy penetration of topical ointment and polyethylene glycol also used as penetrating enhancer in the formulation. All formulations of ethosomes and niosomes based oxiconazole gel subjected for evaluation study. Dissolution study confirms that formulation N15 (niosome) has shown better result in controlling oxiconazole up to 98% in 12h as compare to ethosome. The kinetic release study follows non fickian behavior. Formulation N15 subjected for ex vivo and in vivo diffusion study and shows optimum release rate as compare with commercially available oxiconazole gel.

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