FORMULATION DEVELOPMENT AND EVALUATION OF TRIAMCINOLONE ACETONIDE INTRAMUSCULAR IN-SITU NANO SUSPENSION

Author(s): M. Sunitha Reddy* and K. Sindoori

Abstract: Triamcinolone acetonide is a steroidal anti-inflammatory drug. The patients who are suffering from auto immune diseases like Rheumatoid arthritis treated with Triamcinolone Acetonide, which binds to the Glucocorticoid receptor leading to the activation of anti – inflammatory transcription factors there by it suppresses the activity of immune system. The main objective of the present work is to prepare and evaluate Triamcinolone Acetonide intra muscular in situ nano suspension. The nano suspension was prepared by Micro fluidization technology, with different polymers like poloxamer 407 and poloxamer 188 which forms in-situ gel at body temperature. The prepared in situ nano suspension was evaluated for official parameters. The release profile of optimized formulation has shown 101.06 ±0.68 release in 12 hours respectively with particle size 429.7±4.10 nm, pH 6.5, osmolarity 289osm/L. Three months accelerated stability studies was studied at (25±2C0 / RH 60± 5%) and (40±2C0/ RH 75± 5%) and no significant changes were observed.

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