EFFECT OF ACACIA FARNESIANA ON SOD AND CAT ENZYMES IN ETHANOL INDUCED GASTRIC ULCER RATS

Author(s): Dwarakanath.V* and R.G. Sharathchandra

Abstract: Experimentation was conducted to test the hypothesis that leaves has antioxidant activity. For this purpose, a study was designed using alcoholic extracts of leaves produce significant antioxidant activity. 125 to 150g weighing rats (Wistar albino) aging around one or two months of age are selected for this experimentation. The activity was tested in wistar albino rats at dose levels of 200mg/kg, orally and compared with (20mg/kg) as standard. During the ulcer condition, there was a decline in the levels of Super oxide dismutase [SOD] and catalase [CAT]. This indicated that the generation of relative oxygen species during stress might be the causative factor for the inactivation of these enzymes. The methanol leaf extract of Acacia farnesiana has shown ulcer protective effect as dose dependently against ethanol induced gastric ulcer in rats. The said extract of Acacia farnesiana was found to decrease ulcer and acid pepsin secretion. A change was also seen in SOD, CAT, levels in rat gastric mucosa due to antioxidant property of alcoholic leaves extract of Acacia farnesiana. Antioxidant defense mechanism of the extract was probably due to metabolizing and scavenging H2O2.

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