DEVELOPMENT AND IN VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF GLIPIZIDE

Author(s): Sachin B Aglawe*, Amol U Gayke, Rahul C Jagdale, Rambhau V Vise, Vishal R Gaikwad and Rameshwar B Dhule

Abstract: The objective of present study is to prepare mucoadhesive buccal tablets of Glipizide using the bioadhesive polymers Carbopol 974P (CP) in combination with cashew nut tree gum, Aegle marmelos gum, Moringa Oleifers gum as binding agent and Ethyl cellulose (EC-50 mg) as impermeable backing layer. Nine formulations of mucoadhesive buccal tablets of Glipizide were prepared, which contain the polymers in various combinations. Tablets were prepared by direct compression method and characterized for swelling studies, surface pH, bioadhesive properties, in-vitro drug dissolution and in-vitro diffusion studies. All the formulations show the satisfactory results in terms of bioadhesive performance. The swelling index was proportional to polymer content. The surface pH of all tablets was found to be satisfactory, close to neutral pH; the Glipizide released and drug diffusion from these tablets was depended on the ratio and type of the natural polymers used in the formulation. All the formulations hardness, weight variation, friability and drug content values were found to be within pharmacopoeia limits. As the amount of polymer in the tablets increase, the drug release rate decreases, whereas swelling index and mucoadhesive strength increases Drug polymer interaction were evaluated by Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry.

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