VALIDATED STABILITY INDICATING METHODS FOR THYMOQUINONE USING HPLC AND HPTLC

Author(s): Mrinalini C. Damle*, Aparna Zirange and Shivani Jadhav

Abstract: A stability indicating assay method was developed and validated according to the ICH guidelines for estimation of Thymoquinone using HPLC & HPTLC. HiQSil C18 column was used with Acetonitrile as mobile phase. Wavelength selected was 253 nm. HPTLC analysis was done using precoated silica plates. Toluene was used as mobile phase & detection wavelength was 253 nm. Drug was subjected to forced degradation studies. Validation was carried according to ICH guidelines.

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