DESIGN AND CHARACTERIZATION OF APREMILAST LOADED EMULGEL FOR TOPICAL TREATMENT

Author(s): G.Ganarajan*, Deepak Chandra Sharma*, Pranshu Tangri*, Preeti Kothiyal*

Abstract: The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Apremilast. Apremilast is Anti-psoriasis/ non-steroidal anti-inflammatory drug that has two major problems when administered orally; first is solubility of drug and has irritant effect in GIT can cause ulcerative colitis with bleeding. Apremilast emulgel were prepared using 4 types of gelling agents. The effect of different type of the gelling agent and the concentration of oil phase and emulsifying agent on the drug release was investigated. The prepared emulgel were evaluated for their physical appearance, viscosity, drug release, Spreadability, pH and stability. All the prepared emulgel showed acceptable physical properties: colour, homogeneity, consistency, spreadability, and pH value. The highest drug release from all the prepared emulgel was found to 57.82% at 24 hr. Results revealed that the emulgel formulations exhibited high drug release especially at low polymer concentration. Stability studies of all prepared emulgel showed that the physical appearance, rheological study, in vitro drug release, remained unchanged upon storage for 3 months. So it can be concluded that topical emulgel enhanced permeation of Apremilast and possed an effective anti-psoriosis / anti-inflammatory activity, with avoidance of GIT adverse effect.

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