INHIBITORY EFFECT OF SILVER NANOPARTICLES ON METHICLLIN RESISTANT STAPYLOCOCCUS AUREUS

Author(s): Clemencia Tjazuko, *Sumana M. N, Asha Srinivasan and Rishikesh R Mishra

Abstract: Staphylococcus aureus is a gram-positive coccus causing a wide variety of illnesses; most commonly pyogenic infections. It accounts for 30-50% of skin and soft tissue infections. Over the years there has been an increasing incidence of Methicillin Resistant Staphylococcus aureus. Antimicrobial resistance poses a threat to human health as it leads to increased morbidity and mortality. Due to this antibiotic resistance there is a need for new antibacterial agents that will be effective. Nanoparticles are gaining popularity as novel antimicrobial agents due to their high surface area to volume ratios as well as their physical and chemical properties. The present study was carried out to document the potential inhibitory effect of silver nanoparticles synthesized using leaf extract of Azadirachta indica (neem) on Methicillin-resistant Staphylococcus aureus (MRSA). A total of 100 MRSA isolates were collected from pus, blood, sputum, endotrachael secretions and drain samples. Antimicrobial assay was performed using the well diffusion method. The silver nanoparticles showed promising results of being able to inhibit the growth of the isolates.

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