In-Silico Design, Synthesis and Evaluation of Some Pyrazolo Pyrazole Derivatives as Anticancer Agents (Research Article)

Author(s): Geethanjaly N S and Manju P T

Abstract: Pyrazole is chemically known as 1,2-diazole and has become a popular topic of study. The chemistry of pyrazoles and its derivatives is particularly interesting because of their potential application in medicinal chemistry as analgesics, anti-inflammatory, antibacterial, antimalarial, antifungal, and as enzyme inhibitory agents The discovery of new drugs require not only its design and synthesis but also the development of testing method and procedures, which are needed to establish, how a substance operates in the body and its suitability for use as a drug. The aim of the study is to design different pyrazole derivatives using various softwares (eg; ACD lab Chemsketch 12.0, Molinspiration, PASS, Schrodinger). The designed compounds were synthesized. Characterization of synthesized derivatives was done by 1H NMR, MASS and IR spectroscopy. Synthesized derivatives were screened for anticancer activity.

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