A Prospective Observational Study on Prescription Pattern, Treatment Outcomes, and Comparative Therapeutic Evaluation in Cardiac Patients (Research Article)

Author(s): JN. Suresh Kumar, N. Kodanda Ram, P. Keerthi*, P. Jayasree, M. Somasekhar, and Ch. Ajay

Abstract: A Prospective observational study was conducted in the Department of Cardiology at a Vivekananda hospital in Narasaraopet including 100 patients for study duration of 3 months. The main objective of drug utilization research is to assess the rationality of drug use, associated drug interaction and co- morbidities in Myocardial Infarction. Current evidence-based guidelines for best practice recommend that patients should be treated to trial-directed doses for angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor antagonists (ARBs) and β blockers, as first-line therapy, and mineralocorticoid receptor antagonists (MRAs), as second-line therapy, in the management of patients with heart failure with reduced ejection fraction (HFrEF). Despite this, many patients with heart failure either do not receive these guideline-directed medical therapies or receive doses considerably below the guideline-recommended doses. A pan-European study reported that there was widespread under dosing of ACE inhibitors or ARBs and β blockers despite encouraged up titration. Under treatment with doses that are less than 50% of guideline-recommended dose for ACE inhibitors or ARBs and β blockers is associated with poorer prognosis. Angiotensin -converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs), β blockers, and mineralocorticoid receptor antagonists (MRAs) are of proven benefit and are recommended by guidelines for management of patients with heart failure and reduced ejection fraction (HFrEF). We aimed to examine the first prospective multinational data from Asia on prescribing patterns of guideline-directed medical therapies and analyse its effect on outcomes. Coronary Artery Disease (CAD) tissue, occlusion, or spasm of coronary arteries. There is increasing importance of prescription pattern (PPMS) due to a lift in promoting growing concern regarding drug interactions, planned to assess the prescription pattern and cost of selected drugs used in Coronary patients. The drug prescription pattern was noted from cardiology department of multi-specialty tertiary care hospital and cost analysis was performed for the selected drugs. The data was collected by using structured data c total of 107 prescriptions were analysed from 240 patient records. Most of the patients diagnosed with coronary artery disease were in the age group of 61 statistically significant (P<0.01). The most common classes of drugs prescribed were antihypertensives, antiplatelets, antianginals and antihyperlipidemic. The study results showed that the inappropriate use of drugs in CAD increases the cost of treatment and in long term this may even contribute to drug related problems. Interventions are necessary to improve rational drug use of drugs.

PAGES: 121-130  |  32 VIEWS  37 DOWNLOADS