Synthesis, Biological Evaluation of Novel 1-[4-(1H-Pyrrol-1-yl) Phenyl] Ethanone Chalcones as Potential Antimicrobial and Cytotoxic Agents (Research Article)

Author(s): Rakesh Ponaganti and Y. Rajendra Prasad

Abstract: Novel 1-[4-(1H-pyrrol-1-yl) phenyl] ethanone chalcones (CH 01-15) were synthesized by the condensation of 1-[4-(1H-pyrrol-1-yl) phenyl] ethanone with different aromatic aldehydes and characterized using FT-IR, Mass, NMR and elemental analysis. These compounds were evaluated for their antibacterial activity against four micro-organisms, namely Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 443), Pseudomonas vulgaris (MTCC 2421). The synthesized compounds also evaluated for cytotoxic activity against human cancer cell lines. The human tumor cell line panel constituted three cancer cell lines including breast (MCF-7), colon (HT-29) and prostate (DU-145). Among all, compound CH-13 showing greater inhibitory activity against all tested organisms employed with zones inhibition of 33 to 21 mm at a concentration of 150μg/ml. Compounds CH-06 & CH-09 have been found as the next in the order of its antimicrobial potency. In cytotoxic studies, compound CH-02 found to the potent one with IC50 values of 24 μg/mL, 26 μg/mL and 14 μg/mL against MCF-7, HT-29 & DU-105 cell lines respectively. Compound CH-05 was next in order with IC50 values of 28 μg/mL, 27 μg/mL and 16 μg/mL against MCF-7, HT-29& DU-105 cell lines respectively.

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