FORMULATION AND EVALUATION OF FLURBIPROFEN LOADED CHITOSAN MICROSPHERES BY DENATURATION METHOD

Author(s): Y Surendra* and M Vidyavathi

Abstract: The aim of this study was to formulate and evaluate flurbiprofen loaded chitosan microspheres by denaturation method for controlled drug release using glutaraldehyde as crosslinking agent. The prepared microspheres were characterized for their yield and drug loading, as well by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry and Scanning electron microscopy. The in vitro release studies were performed in pH 7.4, phosphate buffer. The prepared microspheres were free flowing and spherical in shape. The drug-loaded microspheres showed 85.64%-92.12% of entrapment and release was extended up to 12h. The infrared spectra showed stable character of flurbiprofen in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. X-ray diffraction patterns showed that there was decrease in crystallinity of the drug. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. It was found that the drug: polymer ratio, the stirring speed, the concentration of surfactant, and the amount of glutaraldehyde used for crosslinking were the most significant variables which influenced the size of the chitosan microspheres under the applied experimental condition.

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