Synthesis, Molecular Docking and Anti-Bacterial Activity of 3-Sulfonamido Substituted Quinazolinone Derivatives (Research Article)

Author(s): Syeda Advia Sanobar*, K. Sruthi, M. Sumakanth and P. Shravani

Abstract: Quinazolines have inhabited a distinctive position in heterocyclic chemistry and its derivatives have attracted considerable interests in recent years for their variable properties in chemistry and pharmacology. Quinazolines are nitrogen containing heterocyclic ring which possesses biological and pharmaceutical importance owing to its diversified activities like antibacterial, anti-tumor, anti-viral, anti-retroviral etc. The 3-sulfonamido substituted Quinazolines were synthesized and the title compounds were then characterized by melting point, TLC, IR, NMR and Mass spectral data. Docking studies were conducted for these derivatives on the PDB ID: 1AJO by using AutoDOCK software. The anti-bacterial activity was checked by using E. coli, B.subtilis, P.aerugenosa and S.aureus.

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