Formulation and Evaluation of Celecoxib Emulgel

Author(s): M. Sunitha Reddy, Syeda Kashifa Tanzeem and S Muhammad Fazal ul Haq

Abstract: The purpose of present study was to formulate and evaluate emulgel system of celecoxib using two gelling agents: Carbapol 934 and Carbapol 940. Two different emulsions were prepared by varying the concentration of oil, surfactant and co-surfactant. Solubility studies of celecoxib in various oils and surfactants was performed among which Liquid paraffin, Span 20 and Tween 80 have shown higher solubility were selected as oil, surfactant and co-surfactant. Compatibility studies showed that there were no physical or chemical interaction between drug and excipients. All prepared formulations were evaluated. In terms of physical properties (like colour, homogeneity, consistency) all the prepared formulations were white in colour, smooth consistency and homogenous. pH of all the formulations were in the range 5.8-6.40. Swelling ability of F4 formulation was more compared to other formulations when performed for 30min. Rheological study (viscosity) of prepared emulgels were determined using Brookfield viscometer, F4 formulation exhibited greater viscosity. Drug content determination studies were performed for all prepared formulations among which F4 exhibited greater drug content. Ex-vivo diffusion study was carried out using Franz diffusion cell and chicken skin as the semi permeable membrane. Among all the prepared formulations optimized formulation was found to be F4 with 90% diffusion rate and follows first order release kinetics (with r2=0.9691).

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