Risk Assessment of Proton Pump Inhibitors in Ckd and Non-Ckd Patients in a Tertiary Care Hospital

Author(s): Nomy P Benny*, Rahul Radhakrishnan and Arul Balasubramanian

Abstract: Background: Proton pump inhibitors are one of the most widely prescribed classes of drugs mainly used for acid suppression therapy for more than 20 years. The approved indication for the use of PPI include gastro esophageal reflux diseases (GERD), peptic ulcer diseases, erosive esophagitis. Methods: A Retrospective observational study was conducted for 3 months who are admitted in the hospital. Patients of both genders were included in the study. From the data of 70 CKD & NON CKD cases, 35 cases were chronic kidney diseases patients and the remaining 35 cases were non chronic kidney diseases patients. The study was carried out by patient history interview, case record analysis and from laboratory values. The results are tabulated by simple statistical methods. Results: A total of 70 CKD and NON CKD Patients with different co-morbidities were included in the study. The Study reveals that 32(91%) of patients was having increased value of creatinine on the last day of treatment with PPI compared to first day in CKD patients and in non CKD patients, the value of normal level creatinine found higher on the last day on PPI than the first day. Evaluation of Quality of Life among CKD patients indicates that 50% of patients scored having medium quality of life. Conclusion: The increase in the value of serum creatinine, blood urea nitrogen and decreased level of sodium (Hyponatremia) were found in CKD patients treated with PPI.

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