Ameliorating Effects of Chrysin on Scopolamine Induced Memory Impairment in Rats: A Pilot Study on Behavioural, Biochemical and Histological Approach

Author(s): Thangarajan Sumathi*, Bhagyalakshmi Purushothaman and Akila Murugan

Abstract: Dementia is a neurodegenerative disorder characterized clinically by a progressive loss of memory and cognitive functions. The primary cause of dementia is brain’s acetylcholine (Ach) deficiency and oxidative stress which analyzed principle pathogenic factors. The present study was to investigate the anti- amnestic effect of chrysin on scopolamine induced behavioural and neurochemical changes in rats. Chrysin (CN) (25mg and 50mg/kg) were orally administrated for 7 days. Dementia was induced on the 7th day by a single injection of Scopolamine (SCP) (1 mg/kg i.p). Study across three cognitive domains spatial, recognition, and associative memory and associated alterations in their oxidative status and neurochemical profile to select appropriate dementia model. Results showed significant decline in different aspects of memory function in all dementia models which was more significant in scopolamine-injected rats. A significant decline in the levels of acetylcholine was also observed. In addition, significant alterations were also seen in oxidative profile indicating that cognitive decline could be associated with increased oxidative stress. Thus, the study reveals the ameliorative effect of Chrysin which has its therapeutic strategies against cognitive dysfunctions.

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