Orodispersible Films - A Future of Modern Drug Delivery System

Author(s): Amin Prakruti Mukund* and Manish P. Patel

Abstract: Orodispersible films (ODFs) have intrigued scientists and researchers in the domain of pharmaceutical formulations and are being looked upon as a novel approach to designing efficient drug delivery systems. ODFs are currently speculated to be an alternative to the conventional solid and liquid oral dosage forms. Orodispersible films are dissolving films or oral drug strips to administer drugs via their absorption in the mouth, ensuring that the drug directly enters systemic circulation It is an alternate platform for molecules that undergo first pass metabolism. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review reflects information regarding formulation ingredients, to focus on benefits, composition, approaches for formulation and challenges in formulation development of fast dissolving oral films. Additionally, the future scope of this innovative dosage form is also well-positioned. It seems that the value of the overall oral thin films market will grow significantly.

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