Acute Toxicity Evaluation of Ethyl Acetate Fraction of Muntingia calabura L. in Animal Model

Author(s): Ninan Jisha, A. Vysakh, V. Vijeesh, MS Latha

Abstract: Muntingia calabura L., commonly known as Jamaican cherry tree, is one among the traditional medicinal plant which is used widely for various human ailments. The different parts of this plant were used by the tribal communities for treating headache, cold, mouth ulcers etc. The ethyl acetate fraction (EFMC) from the crude methanolic extract of Muntingia calabura L. was selected for the acute toxicity evaluation in animal model. Toxicity evaluation experiment was performed by administering EFMC as a single dose. The blood collected was analyzed for biochemical and hematological parameters by the end of the experimental period. Histological examinations of liver and kidney were also carried out to rule out the possible level of toxicity exhibited by EFMC. The results obtained from hematological and biochemical tests indicated that all the parameters evaluated for toxicity were found to be normal. Hence, we can conclude that EFMC did not exert any kind of toxicity upto a dose of 2000mg/kg body weight.

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