Formulation and Evaluation of Gastro Retentive Floating Tablets of Diclofenac Sodium Based on Effervescent Technology

Author(s): Chanam Melody Devi*, Laldinchhana, Lilima Nath, Abhinab Goswami and Himal Barakoti

Abstract: Floating drug delivery systems can prolong gastric retention time by formulating the dosage form with a lower density than that of gastric fluid. This causes the system to float over the gastric contents in the stomach without affecting the gastric emptying rate for a prolonged period of time. The present study was designed with an aim of preparation and in vitro evaluation of floating tablet using diclofenac sodium as a model drug. The tablets were prepared by dry granulation method based on effervescent technology where sodium bicarbonate was used as a gas generating agent. A hydrophilic swellable polymer hydroxypropyl methylcellulose (HPMC) and microcrystalline cellulose (MCC) was used to control the release of drug and buoyancy was achieved by sodium bicarbonate and citric acid. Total of five formulations was prepared with varying concentration of HPMC and MCC. The optimized formulation F5 exhibited 33.17 % drug release in 12 hrs, while the floating lag time was 40 seconds. In-vitro dissolution study showed that the drug release profile can be sustained by increasing the polymer concentration. The study concluded that HPMC along with gas generating agents can be used to develop gastro-retentive floating tablets with desired controlled and complete release of drug for a prolonged period of time.

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