Strategy of Human Defence Peptide Ll-37 in Wound Healing

Author(s): Avvaru Harish*, Jarugula Nagaraja, Manchineni Prasada Rao, Piratla Venkata sai ram

Abstract: The single human cathelicidin peptide LL-37 has been shown to have antimicrobial and anti-biofilm activity against the gram negative and gram positive human pathogen and have wound healing effect. In diabetic patients often have ulcers on their lower limbs that are infected by multiple bio-film forming genera of bacteria, and the elimination of the bio-film has proven highly successful in resolving such wounds in patients. On developing LL-37 for healing of venous leg ulcers but also sees a strong potential to develop LL-37 for use in the treatment of diabetic foot ulcers. LL-37 modulates the inflammatory section of wound healing through unleash of proteins and peptides that govern the inflammatory sequence and this to lead to re-epithelization and closure of the wound. These review summaries known the mechanism of interaction in healing of chronic wounds and with the microbial membrane.

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