Formulation and Evaluation of Olmesartan Medoxomil as Solid Lipid Nanoparticles and Nano Structural Lipid Carriers

Author(s): Nashwa Hassan*, Shereen El-Adawy, Amal Ammar and Ahmed M. Samy, Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, Alarish, Egypt. Department of Pharmaceutics, Faculty of Pharmacy, Al Azhar University, C

Abstract: Objective: The aim of this work was to develop solid lipid nanoparticles (SLN) and Nanostructured lipid carrier (NLC) of an antihypertensive drug Olmesartan medoxomil (OLM) for improving its gastrointestinal uptake and oral bioavailability. Method: High shear homogenization coupled with ultrasonication method was used for the preparation of SLNs and NLCs formulae. Eight formulae of each system were formulated using full factorial design 23. Three independent variables were selected. For NLCs, the variables are: type of liquid lipid (oleic acid or capryol 90) and type and concentration of surfactant (poloxamer 188 or tween 80). For SLNs, due to absence of liquid lipid, this variable was replaced by two concentrations of OLM. Morphology, particle size, and zeta potential are evaluated. Entrapment efficiency and in vitro release studies were performed using dialysis bag method. Results: The results showed neither incompatibility nor physicochemical reaction between the drug and the solid excipients. The particle size ranged from 219.9 to 363.5 nm and from176.8 to 382.2 nm for SLNs and NLCs respectively. Zeta potential of all formulae were negative indicating good stability. The entrapment efficiency was found in the range of 63.23 % to 84.55 % and 77.05 to 90.64 for SLNs and NLCs respectively. The in vitro OLM release demonstrated that drug-loaded formulations gave higher drug release in controlled manner than OLM itself. Conclusion: The results indicated a promising potential of control release and high bioavailability of Nano particulate system. NLC are better carrier system as compared to SLN.

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