Evaluation of Anticancer and Antiinflammatory potential of methanolic extract of green seaweed Ulva fasciata

Author(s): J K. Mini Alphonse*, K R T. Asha and G. Immanuel

Abstract: In the recent times, discovery of metabolites with biological activities from the marine seaweeds has increased significantly to determine their efficacy against the various human diseases. In the present study was conducted to determine the anticancer and anti - inflammatory efficacy of methanolic extract of green seaweed Ulva fasciata. The methanolic extract was characterized by FTIR and GC-MS analysis for determining the functional groups and secondary metabolites present in the extract. The methanolic extract showed the potential activity against the in vitro anti-inflammatory assays (albumin denaturation, antiproteinase, hypotonicity-induced haemolysis and anti-lipoxygenase activities). The Hep2 cancer cells inhibition of the U. fasciata methanolic extract was observed in a dose dependent manner and increasing of activity with increasing of oncentrations. The maximum activity was displayed in 500μg/ml for 65% and the minimum activity was noticed in 100μg/ml. The IC50 value U. fasciata was documented as 402.16μg/ml. This result suggested that the active fraction can be used in pharmaceutical applications.

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