Antiplasmodial Activity of Alstonia Scholaris

Author(s): M. Swapna Reddy and B. Ramya Kuber

Abstract: As there is an increasing resistance to available antimalarial agents, there is a broad consensus on the need to develop new antimalarial drugs. 4-day suppressive test and Ranes tests were used to evaluate the Antiplasmodial activity of the Ethanolic Bark extract of Alstonia scholaris against P. falcipuram infection in mice by determining parasitemia and percentage inhibition. In addition, each pre-treated mouse was used daily and monitored for the determination of survival time, rectal temperature, packed cell volume (PCV) and also body weight was recorded regularly. Out of all the doses of the bark extracts B600 exhibited more significant parasite suppression, prevented the reduction of temperature, loss of weight and was also capable of significantly increasing the survival time in comparison with control. The bark extract in a dose-dependent manner reduced parasitemia by 59%, 66%, and 95% for doses of B200, B400, and B600, respectively, compared to the controls. The inhibition by CQ15 was significantly higher than the inhibition by B200 and B400 but it was not statistically significant with B600. Further studies are required to determine the chemical constituents responsible for the antimalarial activity of Alstonia scholaris.

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