Anti-Hyperglycemic Evaluation of Extracts of Spinacia oleracea Linn. and Acacia nilotica Linn. in Alloxan induced Diabetic Rats

Author(s): Shrinivas K Sarje*, Nitin B Ghiware, Sachin Bhosale, Payal Chavan

Abstract: Aim of the study- The study was designed to investigate the Anti-hyperglycemic activity of extracts of Spinacia oleracea Linn. and Acacia nilotica Linn. in Alloxan induced diabetic Rats. Material and Methods- The leaves of Spinacia oleracea Linn. were extracted using petroleum ether, chloroform, ethyl acetate and methanol and pods of Acacia nilotica Linn. were extracted using petroleum ether, chloroform, ethyl acetate and ethanol, all the extracts were screened for presence of various phytoconstituents. Diabetes was induced by single dose of intraperitoneal injection of Alloxan monohydrate 120 mg/kg. The test extract were given from day 0 to 21 and on day 0,7,14 and 21 blood glucose and body weight was checked. Results- on day 21 standard drug Glimepiride treated rats showed highly significant p<0.001 while Spinacia oleracea leaves extracts and Acacia nilotica pods extracts showed significant reduction in blood glucose level from day 7 onwards over diabetic control. Conclusion- the antihyperglycemic activity of the extracts may be through its insulinogenic effects as it may have the ability to enhance the activity of insulin within the body.

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