Preparation of Terbinafine Hydrochloride Cubosomes: Preformulation Studies

Author(s): Samuel AJ * and Mulla SA

Abstract: Cubosomes are self-assembled liquid crystalline particles that can be used for carrier potential of hydrophilic, lipophilic and amphiphilic drugs as compared to free drug directly to the particular site of action, thus allow drug targeting and the sustained or controlled release of conventional medicines. Terbinafine hydrochloride (TB-HCl) is a synthetic allylamine antifungal agent. The present research was aimed at preformulation characterization of TB-HCl. The drug was characterized for its micromeritic properties, DSC, XRD, FTIR etc. The standard plot indicates high linear correlation between concentration of drug and absorbance. This data further provide a basis for the development of topical cubosomal formulation.

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