Spectrophotometric Study of Amlodipine Complexation with Some Transition Metal Ions

Author(s): Namita Bhardwaj* and Archana Yadav

Abstract: The present work involves the physicochemical study of the interaction of Amlodipine with some transition metal ions Co (II), Ni (II), and Cu (II). Amlodipine belongs to a class of drugs known as calcium channel blockers and used to treat chest pain (angina), high blood pressure (hypertension) and kidney problems. Stoichiometry of Amlodipine complexes formed in the solution was determined spectrophotometrically applying mole ratio method. The logarithmic constants (log Kf) and the free energy changes (ΔG) of the formed complexes were calculated from the data of mole ratio methods Amlodipine complexes in the UV-Vis region exhibit maximum absorption at 300, 350, 450 nm for Co(ll), Ni(ll), Cu (II) complexes respectively using same amount of metal ion as a blank. The stability constant were found in the order Co < Ni < Cu which obey the Irving-William natural order.

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