Changing Trends in Distribution and Antifungal Susceptibility Pattern of Candida Species Isolated from Various Clinical Samples at A Tertiary Care Hospital, Jaipur

Author(s): Jogender, Anjali Kulshrestha*, Jitender, Jitesh, Suman Rishi

Abstract: The changing epidemiology from Candida albicans to Non-albicans Candida along with increasing antifungal resistance is a matter of great concern in health care settings. The studies on Candida have largely been carried out by the morphological identification but to the best of my knowledge very little work has been done in Rajasthan to find out antifungal susceptibility pattern of Candida species. Keeping in view the above facts, this study was undertaken for identification and evaluation of antifungal susceptibility pattern of Candida species isolated from various clinical samples in a tertiary care hospital, Jaipur. A total of 51 candida species were isolated during a period from Jan 2017- May 2017 and identified by standard microbiological procedures. Antifungal susceptibility testing was carried out on the basis of CLSI M44-A guidelines. Out of 51 Candida isolates, 23 were candida albicans and 28 were Non-albicans candida. Among Non – Candida albicans, 17 isolates were C.tropicalis, 9 and 2 isolates were C. krusei and C. glabrata respectively. Candidiasis was more commonly found in female patients and in 20-39 years of age group. Overall, antifungal susceptibility of Candida species to Fluconazole was 57%, Voriconazole 76%, 88% to Amphotericin B and 94 % to Nystatin. Therefore, The changing trends in epidemiology of candidiasis, necessitates the speciation of candida species which inturn facilitate the development of effective measures to prevent and control transmission of resistant pathogen.

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