ALPHA CYPERMETHRIN INDUCED OXIDATIVE STRESS AND ITS AMELIORATION BY RESVERATROL IN LIVER OF MICE

Author(s): A.J. Koshti*and R.J. Verma

Abstract: Present study was undertaken to study the ameliorative potential of resveratrol on alpha cypermethrin induced oxidative stress in liver of mice. The insecticide was administered orally at 7 mg/kg body weight to female mice for period of thirty days. In another sets of experiment animals were treated with three different doses (50 mg/kg body weight, 100mg/kg body weight and 150mg/kg body weight) of resveratrol along with 7 mg/kg body weight alpha cypermethrin. Besides these, there were untreated control, vehicle control and resveratrol (antidote) control groups. For evaluating oxidative stress in liver of mice, enzymes of oxidative stress like Superoxide dismutase, Catalase, Glutathione peroxidase, Glutathione reducatse and Glutathione-S-tansferase were assayed in all experimental groups. Result revealed that alpha cypermethrin reduced all these enzymes level significantly p<0.05compared to alpha cypermethrin alone group. It is concluded that resveratrol ameliorates alpha cypermethrin induced oxidative stress in liver of mice.

PAGES: 879-884  |  47 VIEWS  181 DOWNLOADS