HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF THE EHANOLIC EXTRACTS OF Boerhaavia Diffusa L AND Cichorium Intybus L CCl4 – INDUCED HEPATIC DAMAGE IN RATS

Author(s): Bharathi. K* and Thirumurugan V

Abstract: In traditional medicine Boerhaavia diffusa and Cichorium intybus are used as a hepatoprotective and antioxidant drugs. The aim of the present study is designed to evaluate the hepatoprotective, and antioxidant properties of Boerhaavia diffusa and Cichorium intybus leaf powder (drug) in experimental albino rats study and access toxicity related drugs through histopathology studies in drug treated animals. The LD50 value of the ethanolic extract of two plants are found out by acute toxicity studies. It is found out that both plants have greater than 2000 mg/kg as none of the animals has experienced any signs of toxicity nor death. The ethanolic extract of Boerhaavia diffusa and Cichorium intybus leaf powder (100 mg / kg and 200 mg / kg individually and combination of two plant extract 100 mg / kg and 100 mg / kg) are administered respectively to the animals. The drug CCl4, used to induce the hepatotoxicity and the drug silymarin (25.0 mg / kg) is given as the reference standard. The both plant extracts are effective in protecting the liver aginst the hepatotoxicity induced by the CCl4 in rats. This is evident from the significant reduction in Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) , Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), and total bilirubin levels and also effective against free radical scavenging activity by significant reduction in enzyme parameters like Glutathione peroxidase, Super Oxide Dismutase (SOD), Catalase, Thiobarbituric Acid Reactive Substance (TBARS). It is concluded from the result that the ethanolic extract of Boerhaavia diffusa and Cichorium intybus leaf powder possesses good hepatoprotective activity and antioxidant against CCl4 induced hepatotoxicity in albino rats. Further studies are required to isolate and characterize the active principles which are responsible for the hepatoprotective efficacy of this medicinal plants.

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