HEPATICHYPOLIPIDEMIC POTENTIAL OF SEAWEED, Padina gymnospora (KUTZING) ON STREPTOZOTOCIN INDUCED DIABETICS IN MALE ALBINO WISTAR RATS

Author(s): M. Rajakani, M. Muthulingam and R. Karuppasamy*

Abstract: Diabetes mellitus is a multisystem endocrine disorder characterized by persistent hyperglycemia resulting from the defects in insulin secretion, action or both. In the traditional system of Indian medicine, formulation with extracts of plant parts is used as the drug of choice as antidiabetic, antiulcerative, hepatoprotective and lipid-lowering agents. Herbal medicines are popular remedies for a number of diseases and used by a vast majority of the world’s population. Since pre-historic times, herbs were the basis for nearly all medicinal therapy until synthetic drugs were developed in the nineteenth century. Seaweeds contain polysaccharides, proteins, amino acids, lipids, peptides, minerals and some vitamins. Polyphenols of seaweed are used as cosmetics and pharmacologicalsas antioxidants, protection from radiation, antibiotics and anti–inflammatory, hypo–allergenic, antibacterial and antidiabetic activity. The present study was undertaken to investigate the effect of methanolic extracts of Padina gymnospora on streptozotocin induced diabetics in male albino Wistar rats. Streptozotocin induced diabetic rats were treated with methanolic extracts of Padina gymnospora at the doses of 50, 100 and 200 mg/kg, p.o. and its influence on total cholesterol, phospholipids, triglycerides and free fatty acids in liver were observed. Oral administration of methanolic extract of Padina gymnospora at the doses of 50, 100 and 200 mg/kg, p.o. to streptozotocin treated rats showed significantly decreased in total cholesterol, phospholipids, triglycerides and free fatty acids in liver near normal. Hence, it can be concluded that methanolic extract of Padina gymnospora effectively reduce the lipid profiles in diabetic rats.

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