RENAL HYPOLIPIDEMIC EFFICACY OF SEAWEED, Padina gymnospora (KUTZING) ON STREPTOZOTOCIN INDUCED DIABETICS IN MALE ALBINO WISTAR RATS

Author(s): M. Rajakani, M. Muthulingam and R. Karuppasamy*

Abstract: Plants have been considered as sources of medicinal agents for the treatment of many diseases. The renal hypolipidemic efficacy of seaweed, Padina gymnospora was evaluated by streptozotocin induced diabetics in rats. Male albino wistar rats were orally treated with seaweed, Padina gymnospora methanolic extracts (50, 100 and 200 mg/kg body weight) or glibenclamide (600 μg/kg) daily with administration of streptozotocin (45 gm/kg body weight- ip) only one day. Streptozotocin induced diabetics and significantly increased the levels of total cholesterol, free fatty acids, triglycerides and phospholipids in kidney as compared with control group. Treatment with seaweed, Padina gymnospora methanolic extracts or glibenclamide consecutively for forty-five days could significantly decrease the levels of renal lipid profiles when compared with streptozotocin alone treated rats.

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