ASSESSMENT OF ANTIOXIDANT, ANTI-LIPID PEROXIDATION, DNA DAMAGE PROTECTION AND ANTICANCER ACTIVITIES OF MARINE MANGROVE FUNGI

Author(s): J.S. Kushveer, Rashmi Mishra, B. Devadatha, Mohd Imran K Khan and V.V. Sarma*

Abstract: Marine fungi are still a less explored group of microorganisms for novel medicinal properties that may have medicinal and pharmacological applications. In the present study, 55 marine fungi were screened for in-vitro antioxidant potential. Three marine fungi were shortlisted based on their higher antioxidant activity and were subjected to further studies including estimation of total phenolic & flavonoid content, qualitative screening of secondary metabolite groups and anticancer activity. Potential marine fungal isolates were identified and characterized based on their morphology and molecular phylogenetic analyses. The antioxidative properties of crude extracts derived from marine fungi were evaluated employing various in-vitro methods viz., DPPH, ABTS, nitric oxide radical scavenging assay, reducing power assay, anti-lipid peroxidation assay, oxidative DNA damage protection and cell viability assay. Among the three fungi, Marasmiellus sp. (PUK-64) showed highest antioxidant activity followed by Hypoxylon sp. (PUK-4) and Scedosporium aurantiacum (PUK-60). Marasmiellus sp. not only showed highest radical scavenging activity but also had highest phenolic and flavonoid contents. This study has demonstrated a notable antioxidant potential in the selected marine fungi in addition to appreciable anti-cancerous activity.

PAGES: 291-310  |  46 VIEWS  189 DOWNLOADS