ROLE OF TRPV1 CHANNELS IN ISCHEMIA –REPERFUSION INJURY OF MYOCARDIUM

Author(s): Mihir K. Patel, Yagnik S. Bhalodia and Anita A. Mehta

Abstract: Transient receptor potential vanilloid 1 (TRPV1) channels are cation specific channel responsible for pain sensation. Besides its role in pain sensation, it plays a pivotal role in ischemia reperfusion injury of myocardium. Activation of transient receptor potential vanilloid 1 channel diminishes ischemia-reperfusion induced injury in myocardium. Sensory neurons innervating the myocardium express vast amount of transient receptor potential vanilloid 1 channels. During ischemic conditions, activation of TRPV1 channels on the perivascular nerves stimulates the release of calcitonin gene-related peptide and substance P to offer cardioprotection. Moreover, activation of TRPV1 channel helps to reduce production of the of free radicals and inflammatory cytokines, inhibits neutrophil infiltration, and increases the production of anti-inflammatory cytokines to diminish ischemia–reperfusioninduced tissue injury various organs including the heart. The current review highlights the potential role of TRPV1 channels and the signaling cascade in cardioprotection against ischemia–reperfusion injury.

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